Carlo Franchini Selected Research

Mexiletine (Mexitil)

1/2021	Synthesis and Evaluation of Voltage-Gated Sodium Channel Blocking Pyrroline Derivatives Endowed with Both Antiarrhythmic and Antioxidant Activities.
1/2017	Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity.
7/2013	Searching for new antiarrhythmic agents: evaluation of meta-hydroxymexiletine enantiomers.
2/2012	Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels.

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Carlo Franchini Research Topics

Disease

6	Myotonia 12/2021 - 02/2012
5	Neoplasms (Cancer) 01/2022 - 01/2016
4	Infections 07/2021 - 12/2013
3	Inflammation (Inflammations) 06/2021 - 01/2017
2	Multiple Myeloma 01/2022 - 01/2017
2	Pain (Aches) 01/2018 - 01/2015
2	Neuralgia (Stump Neuralgia) 01/2018 - 02/2012
2	Carcinoma (Carcinomatosis) 06/2016 - 09/2013
2	Adenocarcinoma 06/2016 - 09/2013
2	Chronic Pain 01/2015 - 02/2013
1	Breast Neoplasms (Breast Cancer) 01/2022
1	Morning Sickness 01/2022
1	Diarrhea 02/2021
1	COVID-19 01/2021
1	Pneumonia (Pneumonitis) 01/2021
1	Reperfusion Injury 01/2021
1	Premature Aging 05/2020
1	Cardiovascular Diseases (Cardiovascular Disease) 05/2020
1	Cataract (Cataracts) 05/2020
1	Fissure in Ano (Anal Fissure) 02/2019
1	Orthostatic Hypotension (Postural Hypotension) 02/2019
1	Pruritus (Itching) 02/2019
1	Obesity 01/2019
1	Pediatric Obesity 01/2019
1	Tinnitus 01/2018
1	Trigeminal Neuralgia (Tic Douloureux) 01/2018
1	Myotonic Disorders (Paramyotonia Congenita) 01/2018
1	Stroke (Strokes) 11/2017
1	Chronic Kidney Failure (Chronic Renal Failure) 11/2017
1	Embolism (Embolus) 11/2017
1	Chronic Renal Insufficiency 11/2017
1	Hemorrhage 11/2017
1	Renal Insufficiency (Renal Failure) 11/2017
1	Atrial Fibrillation 11/2017
1	Crohn Disease (Crohn's Disease) 01/2017
1	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2017
1	Erythema Nodosum 01/2017
1	Sarcoidosis (Schaumann Disease) 01/2017
1	Rheumatoid Arthritis 01/2017
1	Cardiac Arrhythmias (Arrythmia) 07/2013
1	Epilepsy (Aura) 02/2013
1	Mycoses (Diseases, Fungus) 07/2012

Drug/Important Bio-Agent (IBA)

5	Pharmaceutical PreparationsIBA 01/2022 - 07/2012
4	Sodium Channel BlockersIBA 12/2021 - 02/2013
4	Mexiletine (Mexitil)FDA LinkGeneric 01/2021 - 02/2012
3	Tocainide (Tonocard)FDA Link 12/2021 - 03/2014
3	lubeluzoleIBA 02/2021 - 09/2013
2	Thalidomide (Thalomid)FDA Link 01/2022 - 01/2017
2	PolyphenolsIBA 06/2021 - 01/2019
2	Anti-Bacterial Agents (Antibiotics)IBA 02/2021 - 01/2021
2	Biocompatible Materials (Biomaterials)IBA 03/2016 - 12/2013
1	CosmeticsIBA 07/2021
1	Anti-Infective Agents (Microbicides)IBA 07/2021
1	triclocarbanIBA 07/2021
1	Antiviral Agents (Antivirals)IBA 01/2021
1	AntioxidantsIBA 01/2021
1	Cardiotonic Agents (Cardiac Stimulants)IBA 01/2021
1	Vitamin E FDA LinkGeneric 05/2020
1	Diltiazem (Cardizem)FDA LinkGeneric 02/2019
1	GelsIBA 02/2019
1	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 01/2019
1	AnticoagulantsIBA 11/2017
1	Warfarin (Coumadin)FDA LinkGeneric 11/2017
1	apixabanIBA 11/2017
1	Proteins (Proteins, Gene)FDA Link 01/2017
1	Sodium Channels (Sodium Channel)IBA 01/2017
1	Hypnotics and Sedatives (Sedatives)IBA 01/2017
1	Interleukin-6 (Interleukin 6)IBA 01/2017
1	NF-kappa B (NF-kB)IBA 01/2017
1	Neuroprotective AgentsIBA 06/2016
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2016
1	Voltage-Gated Sodium ChannelsIBA 01/2015
1	Doxorubicin (Adriamycin)FDA LinkGeneric 09/2013
1	Paclitaxel (Taxol)FDA LinkGeneric 09/2013
1	Vasodilator Agents (Vasodilators)IBA 07/2013
1	Protein Isoforms (Isoforms)IBA 02/2013
1	ProdrugsIBA 02/2012

Therapy/Procedure

3	Therapeutics 02/2019 - 01/2018
1	Renal Dialysis (Hemodialysis) 11/2017
1	Contraindications 01/2017
1	Drug Therapy (Chemotherapy) 02/2013